Asector

Asector® 20 Capsule: Each capsule contains Esomeprazole Magnesium Trihydrate equivalent to 20 mg Esomeprazole INN as enteric coated pellets. Asector® 40 Capsule: Each capsule contains Esomeprazole Magnesium Trihydrate equivalent to 40 mg Esomeprazole INN as enteric coated pellets
Esomeprazole is a proton pump inhibitor used to treat ulcers, Gastro-esophageal reflux disease (GERD), or Zollinger-Ellison syndrome. Esomeprazole is S-isomer of Omeprazole.
Esomeprazole suppresses gastric acid secretion by specific inhibition of the H+/K+_ATPase in the gastric parietal cell. The S-isomers of Omeprazole are protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose related up to a daily dose of 20 to 40 mg and leads to inhibition of gastric acid secretion.
1. Initial treatment for healing of reflux esophagitis. 2. Initial treatment of heartburn and other symptoms of GERD. 3. Daily treatment to prevent relapse of reflux esophagitis. 4. Risk reduction of NSAID-associated Gastric Ulcer. 5. Long-term management of recurrent heartburn and other symptoms of GERD with on demand treatment. 6. Healing of H. pylori associated duodenal ulcer. 7. H. pylori eradication for prevention of recurrence of H. pylori associated duodenal ulcer. 8. Pathological hypersecretory conditions including Zollinger-Ellison Syndrome.
Esomeprazole, Delayed-Release Capsules should be swallowed whole and taken at least one hour before meal. Recommended adult dosage schedule:
No dosage adjustment is necessary.
No dosage adjustment is necessary
No dosage adjustment is necessary in patients with mild to moderate liver impairment. For patients with severe liver impairment, a dose of 20 mg of Esomeprazole should not be exceeded.
No dosage adjustment is necessary
The safety and effectiveness of Esomeprazole in pediatric patients < 1 year of age have not been established.
More common side effects may include: Abdominal pain, diarrhea, headache, dermatitis etc.
The effects of Esomeprazole during pregnancy have not been adequately studied. Those who are pregnant or plan to become pregnant should consult with the doctor. Because Esomeprazole is likely to appear in breast milk and could harm a nursing infant, so need to choose between taking Esomeprazole or breastfeeding your baby.
In case of overdose, seek medical attention immediately. Symptoms of overdose may include: Blurred vision, confusion, drowsiness, dry mouth, flushing, headache, nausea, rapid heartbeat and sweating etc.
Esomeprazole is contraindicated in patients with known hypersensitivity to Esomeprazole or to substituted Benzimidazoles.
Before taking this medicine, tell your doctor if you have:  a compromised immune system  asthma  COPD This medicine may increase the risk of pneumonia in some patients.
Esomeprazole is taken with certain other drugs; the effects either could be increased, decreased or altered. Esomeprazole inhibits gastric acid secretion. Therefore, Esomeprazole may interfere with the absorption of drugs where gastric pH is the important determinant of bioavailability (e.g. Ketoconazole, Iron salts and Digoxin). Co-administration of oral contraceptives, Diazepam, Phenytoin or Granidine does not seem to change the pharmacokinetic profile of Esomeprazole. Co-administration of Esomeprazole, Clarithromycin and Amoxycillin has resulted in increases in the plasma levels of Esomeprazole and 14-hydroxyclarithromycin.
Store in a cool and dry place and keep away from light
Asector® 20 capsule: Each box contains 6 Alu-alu blister strips of 10 capsules each. Asector® 40 capsule: Each box contains 7 Alu-alu blister strips of 4 capsules each.
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